Poor Pharma. Until 15 years ago, hormone replacement therapy (HRT) was a right of passage for older U.S. women and Pharma raked in billions. While HRT did prevent osteoporosis, it was also found to increase the risk of breast cancer, stroke, blood clots, hearing loss, gall bladder disease, urinary incontinence, asthma, the need for joint replacement, melanoma, ovarian, endometrial and lung cancers, non-Hodgkin's lymphoma and even dementia according to medical findings. In the first year that millions of women quit HRT in 2003, U.S. breast cancer fell seven percent and 15 percent in women with estrogen fed tumors.